The analysis did not support the use of opioids (including oxycodone and hydrocodone) as the sole or preferential form of treatment for chronic non-cancer-related pain.

A meta-analysis (detailed review) of 46 studies showed no significant difference in pain relief between opioids and other pharmacological (such as NSAIDs) or non-pharmacological treatments (such as psychotherapy or physiotherapy). When used for chronic non-cancer-related pain, trials DO NOT support the use of opioids over other forms of pain relief. 5 The incidence of side effects such as nausea, vomiting, itching, or drowsiness were similar however, constipation was more likely to be experienced by people taking hydrocodone patients (21% of hydrocodone patients reported constipation in one study compared with no oxycodone patients). 1,2,3,4įor acute severe pain, such as that following a fracture, no difference in effectiveness at relieving pain was noted between oxycodone 5mg and hydrocodone 5mg (both were given in combination with acetaminophen). See also: Compare Tool - Oxycodone vs Hydrocodone Long answer Are there any studies that compare oxycodone to hydrocodone?įor cancer-related pain, a number of different studies have concluded that both oxycodone and hydrocodone have similar effectiveness at relieving pain. Hydrocodone is also effective as a cough suppressant.īoth are available in abuse-deterrent forms. Oxycodone appears to have a higher abuse liability potential compared with hydrocodone. Hydrocodone is not widely available outside of the U.S., so has limited use internationally. Studies have shown no differences in their pain-relieving properties however, the incidence of constipation may be higher with hydrocodone.

Oxycodone and hydrocodone are both narcotic analgesics indicated for the relief of moderate-to-severe cancer-related or acute pain.

Norco 7.5325 mg